Stress in utero: effects on gliovascular integrity in female infant offspring
Rodrigues, M.; Sousa, I.; Baptista, F.; Coelho-Santos, V.
Show abstract
From early in life, experiences like prenatal stress profoundly affect long-term health and behavior. Maternal stress increases fetal exposure to glucocorticoids (GC), disrupting neurodevelopment and raising susceptibility to psychiatric disorders. Previous studies on synthetic GCs, such as dexamethasone (DEX), revealed impairments in neurogenesis and dendritic spine development. However, the influence of prenatal stress on the gliovascular interface remains unclear. This interface, involving the relationship between astrocytes and blood vessels, is essential for healthy brain development. Our study demonstrates that prenatal stress alters the expression and localization of astrocytic proteins crucial for maintaining vascular homeostasis, such as aquaporin-4, in female offspring exposed to DEX. While overall vascular density remains unaffected, it triggers morphological changes. Particularly, the hippocampus and prefrontal cortex exhibit heightened vulnerability to these effects. This study reveals prenatal stress as a potent disruptor of gliovascular development, urging deeper inquiry into its implications.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Early-life obesogenic environment integrates immunometabolic and epigenetic signatures governing neuroinflammation 94%
- LPS-Induced Inflammation Reduces GABAergic Interneuron markers and Brain-derived Neurotrophic Factor in Mouse Prefrontal Cortex and Hippocampus 94%
- Effects of combined prenatal exposure to air pollution and maternal stress on immune and dopaminergic gene expression in the gut-brain axis 94%
Similar papers in this journal
- Maternal Immune Activation Alters Temporal Precision of Spike Generation of CA1 Pyramidal Neurons by Unbalancing GABAergic Inhibition in the Offspring 93%
- Environmental influences on placental programming and offspring outcomes following maternal immune activation 93%
- Traumatic stress history interacts with chronic peripheral inflammation to alter mitochondrial function of synaptosomes in a sex-specific manner 93%
Similar papers in this journal
- Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats 94%
- Ovarian hormone status dictates the neuroinflammatory and behavioural consequences of sub-chronic stress exposure in middle-aged female mice 93%
- Rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK) targets glucocorticoid receptor signaling: a longitudinal cerebrospinal fluid proteome study 93%
Similar papers in this journal
- Microglial synaptic pruning on axon initial segment of dentate granule cells: sexually dimorphic effects on fear response of adult rats subjected to early life stress 95%
- Vasopressin acts as a synapse organizer in limbic regions by boosting PSD95 and GluA1 expression 95%
- Nucleus of the lateral olfactory tract (NLOT): a hub linking water homeostasis-associated SON-AVP circuit and neocortical regions to promote social behavior under osmotic challenge 93%
Similar papers in this journal
- Early neuroadaptations to an obesogenic diet identify the schizophrenia-related ErbB4 receptor in obesity-induced hippocampal abnormalities 94%
- Perineuronal nets affect memory and learning after synapse withdrawal 93%
- Exposure to maternal high-fat diet induces extensive changes in the brain of adult offspring 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.