Giardia Increases Macrophage Production of the Anti-Inflammatory Cytokine Interleukin-10 in Response to Lipopolysaccharide via Macrophage Galactose Binding Lectin (MGL1)
Angelova, V.; Darmadi, M.; Miskovsky, E.; Fink, M.; Menegas, S.; Wexelblatt, H.; Singer, S. M.
Show abstract
Giardia duodenalis is an intestinal protozoan parasite, common in low- and middle-income countries. Infection is frequently subclinical, even when it is associated with other pathologies like growth stunting in children. Recent longitudinal cohort studies have found Giardia more frequently in patients with milder symptoms and have even suggested that Giardia reduces rotavirus symptom severity. One potential mechanism for limiting disease severity due to other enteropathogens is the promotion of anti-inflammatory responses that limit pathology. Our lab previously showed that Giardia reduced production of IL-12 by dendritic cells stimulated with TLR agonists. In this study, we show that Giardia increases the production of the anti-inflammatory cytokine IL-10 by mouse peritoneal macrophages in response to bacterial LPS. This potentiation is specific to IL-10, as no changes were seen in the production of the pro-inflammatory cytokine TNF-{square}. Moreover, peritoneal macrophages from mice lacking macrophage galactose-binding lectin (MGL1), a pathogen recognition receptor that has been previously shown to bind N-acetylgalactosamine, failed to increase IL-10 production after stimulation with Giardia and LPS. Giardias immunoregulation of the IL-10 response may help us understand the parasites role in reducing diarrheal severity.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Helminth infection driven gastrointestinal hypermotility is independent of eosinophils and mediated by alterations in smooth muscle instead of enteric neurons 93%
- Trickle infection and immunity to Trichuris muris 93%
- Salmonella enterica serovar Typhimurium chitinases modulate the intestinal glycome and promote small intestinal invasion. 92%
Similar papers in this journal
Similar papers in this journal
- A tractable Drosophila cell system enables rapid identification of Acinetobacter baumannii host factors 90%
- Phthiocerol dimycocerosates from Mycobacterium tuberculosis increase the membrane activity of bacterial effectors and host receptors 90%
- Enteropathogenic Escherichia coli (EPEC) Infection Induces Diarrhea, Intestinal Damage, Metabolic Alterations and Increased Intestinal Permeability in a Murine Model 90%
Similar papers in this journal
- Mmp17-deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection 92%
- Inhibition of granuloma triglyceride synthesis imparts control of Mycobacterium tuberculosis through curtailed inflammatory responses 92%
- A truncated form of HpARI stabilises IL-33, amplifying responses to the cytokine. 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.