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Antimicrobial blue light-bathing therapy for wound infection control

Hui, J.; Moon, W.; Dong, P.-T.; dos Anjos, C.; Negri, L.; Yan, H.; Wang, Y.; Tam, J.; Dai, T.; Anderson, R. R.; Goverman, J.; Gelfand, J.; Yun, S.-H.

2024-04-16 bioengineering
10.1101/2024.04.13.589323 bioRxiv
Show abstract

The prevalence of antibiotic resistance and tolerance in wound infection management poses a serious and growing health threat, necessitating the exploration of alternative approaches. Antimicrobial blue light therapy offers an appealing, non-pharmacological solution. However, its practical application has been hindered by the requirement for high irradiance levels, which particularly raises safety concerns. Here, we introduce a light-bathing strategy that employs prolonged, continuous exposure to blue light at an irradiance range lower by more than an order of magnitude (5 mW/cm2). This method consistently applies bacteriostatic pressure, keeping wound bioburden low, all while minimizing photothermal risks. Leveraging tailor-made, wearable light-emitting patches, we conducted preclinical trials on rat models of wound infection, demonstrating its safety and efficacy for suppressing infections induced by methicillin- resistant S. aureus and multidrug-resistant P. aeruginosa. Our results pave a new way for the application of blue light therapy in wound care.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.