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Temporo-spatial cellular atlas of the regenerating alveolar niche in idiopathic pulmonary fibrosis
2024-04-12
respiratory medicine
Title + abstract only
View on medRxiv
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AbstractHealthy repair of the alveoli requires alveolar stem cells to differentiate into cells designed for gas exchange. In chronic lung fibrotic disease like idiopathic pulmonary fibrosis (IPF), alveolar epithelial cells regenerate abnormally. The cause of this is unknown but its highly cellular, inflamed and structurally altered regenerating niche is likely to be relevant. Here, in unique sets of human lung tissues capturing advancing fibrosis, and with a 33-plex single cell imaging mass cyto...
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