Temporo-spatial cellular atlas of the regenerating alveolar niche in idiopathic pulmonary fibrosis
Weeratunga, P.; Hunter, B.; Sergeant, M.; Bull, J.; Clelland, C.; Denney, L.; Vuppusetty, C.; Burgoyne, R.; Woo, J.; Hu, T.; Borthwick, L.; Shaw, J.; Antanaviciute, A.; Filby, A.; Byrne, H.; Fisher, A.; Ho, L.-P.
Show abstract
AbstractHealthy repair of the alveoli requires alveolar stem cells to differentiate into cells designed for gas exchange. In chronic lung fibrotic disease like idiopathic pulmonary fibrosis (IPF), alveolar epithelial cells regenerate abnormally. The cause of this is unknown but its highly cellular, inflamed and structurally altered regenerating niche is likely to be relevant. Here, in unique sets of human lung tissues capturing advancing fibrosis, and with a 33-plex single cell imaging mass cytometry (IMC), we provide a high resolution and comprehensive temporo-spatial cell atlas of the regenerating alveolar niches. Using a suite of mathematical tools, we expose an organized immune network and identify CD206hi alveolar macrophages as a central immune cell in the immune-alveolar epithelial interactome. A spatially-directed receptor-ligand analysis offers an in-silico mechanism by which these macrophages influenced alveolar regeneration. Our study unravels a complex cellular environment and identifies key interactions that influence alveolar regeneration in a fibrotic lung.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Implicating Gene and Cell Networks Responsible for Differential COVID-19 Host Responses via an Interactive Single Cell Web Portal 96%
- Integrative Analysis of Spatial Transcriptome with Single-cell Transcriptome and Single-cell Epigenome in Mouse Lungs after Immunization 94%
- Patterning the embryonic pulmonary mesenchyme 94%
Similar papers in this journal
- Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity 96%
- High-parametric protein maps reveal the spatial organization in early-developing human lung 95%
- Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity 95%
Similar papers in this journal
- Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and thrombosis 94%
- Redundant and additive functions of the four Lef/Tcf transcription factors in lung epithelial progenitors 93%
- IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota 93%
Similar papers in this journal
- Single-nucleus chromatin accessibility identifies a critical role for TWIST1 in idiopathic pulmonary fibrosis myofibroblast activity 95%
- Single-cell RNA-seq reveals spatially restricted multicellular fibrotic niches during lung fibrosis 94%
- Spatial Profiling of Lung SARS-CoV-2 and Influenza Virus Infection Dissects Virus-Specific Host Responses and Gene Signatures 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.