Deep generative AI models analyzing circulating orphan non-coding RNAs enable accurate detection of early-stage non-small cell lung cancer
Karimzadeh, M.; Momen-Roknabadi, A.; Cavazos, T. B.; Fang, Y.; Chen, N.-C.; Multhaup, M.; Yen, J.; Ku, J.; Wang, J.; Zhao, X.; Murzynowski, P.; Wang, K.; Hanna, R.; Huang, A.; Corti, D.; Nguyen, D.; Lam, T.; Kilinc, S.; Arensdorf, P.; Chau, K. H.; Hartwig, A.; Fish, L.; Li, H.; Behsaz, B.; Elemento, O.; Zou, J.; Hormozdiari, F.; Alipanahi, B.; Goodarzi, H.
Show abstract
Liquid biopsies have the potential to revolutionize cancer care through non-invasive early detection of tumors, when the disease can be more effectively managed and cured. Developing a robust liquid biopsy test requires collecting high-dimensional data from a large number of blood samples across heterogeneous groups of patients. We propose that the generative capability of variational auto-encoders enables learning a robust and generalizable signature of blood-based biomarkers that capture true biological signals while removing spurious confounders (e.g., library size, zero-inflation, and batch effects). In this study, we analyzed orphan non-coding RNAs (oncRNAs) from serum samples of 1,050 individuals diagnosed with non-small cell lung cancer (NSCLC) at various stages, as well as sex-, age-, and BMI-matched controls to evaluate the potential use of deep generative models. We demonstrated that our multi-task generative AI model, Orion, surpassed commonly used methods in both overall performance and generalizability to held-out datasets. Orion achieved an overall sensitivity of 92% (95% CI: 85%-97%) at 90% specificity for cancer detection across all stages, outperforming the sensitivity of other methods such as support vector machine (SVM) classifier, ElasticNet, or XGBoost on held-out validation datasets by more than [~]30%.
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