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Combined detrimental effect of male sex and GBA1 variants on cognitive decline in Parkinson's Disease

2024-04-03 neurology Title + abstract only
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Background and ObjectiveHeterozygous variants in the glucocerebrosidase gene (GBA1) are the major genetic risk factor for Parkinsons Disease (PD). GBA-PD has been associated with worse progression and higher risk of cognitive decline. Here we took advantage of the Parkinsons Progression Markers Initiative (PPMI) to investigate whether sex could interact with GBA1 carrier status in determining the clinical phenotype, with a special focus on cognitive decline. MethodsWe evaluated 118 PD subjects ...

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