Desynchronization between timers provokes transient arrest during C. elegans development
Romero-Exposito, F. J.; Moreno-Rivero, A.; Munoz-Barrera, M.; Garcia-Sanchez, S.; Rodriguez-Peris, F.; Gritti, N.; Sartor, F.; Merrow, M.; van Zon, J. S.; Mata-Cabana, A.; Olmedo, M.
Show abstract
In multicellular organisms, developmental timers integrate internal and external cues to control numerous cellular processes that need to be temporally coordinated. The molting timer and the developmental timer run in parallel during C. elegans development. We reveal a novel state of transient arrest of the molting timer upon delay of the developmental timer. This means that synchronous development is not inherent but requires active synchronization of parallel timers. Additional timer variability, like that provoked by modulation of nutrient sensing pathways, increases desynchrony between these timers and consequently extends transient arrest. Mutation of the insulin receptor gene daf-2 reduces the speed of both timers but has a larger impact on the developmental timer, that then appears delayed relative to the molting timer. In this context, prolonged arrest of the molting timer provides a mechanism for resynchronization. TeaserActive resynchronization at specific checkpoints of two parallel timers controlling developmental events.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A TIR-1/SARM1 phase transition underlies p38 immune pathway activation in the C. elegans intestine 96%
- Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons 95%
- A Spatiotemporal Reconstruction of the C. elegans Pharyngeal Cuticle Reveals a Structure Rich in Phase-Separating Proteins 95%
Similar papers in this journal
- The conserved ER-transmembrane protein TMEM39 coordinates with vesicular COPII to promote collagen secretion and prevent ER stress 96%
- The SWI/SNF chromatin remodeling assemblies BAF and PBAF differentially regulate cell cycle exit and cellular invasion in vivo 95%
- Drosophila fabp is a retinoid-inducible gene required for Rhodopsin-1 homeostasis and photoreceptor survival 95%
Similar papers in this journal
Similar papers in this journal
- Epidermal cell fusion promotes the transition from an embryonic to a larval transcriptome in C. elegans 96%
- Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the C. elegans germ line 96%
- The plakin domain of C. elegans VAB-10/plectin acts as a hub in a mechanotransduction pathway to promote morphogenesis 95%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.