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Using absorbance detection for hs-SV-AUC characterization of adeno-association virus

Larson, N. R.; Bou-Assaf, G. M.; Laue, T. M.; Berkowitz, S. A.

2024-03-29 biophysics
10.1101/2024.03.27.587092 bioRxiv
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Data are presented demonstrating that absorbance detection can be used during high-speed sedimentation velocity analytical ultracentrifugation (hs-SV-AUC) experiments to accurately characterize adeno-associated virus (AAV) drug products. Advantages and limitations of being able to use this detector in this specific type of SV-AUC experiment are discussed.

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