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Humoral Immunity Elicited by the XBB.1.5 Monovalent COVID-19 Vaccine

Nguyenla, X. H.; Bates, T. A.; Trank-Greene, M.; Wahedi, M.; Tafesse, F. G.; Curlin, M. E.

2024-03-26 infectious diseases
10.1101/2024.03.25.24304857 medRxiv
Show abstract

As novel SARS-CoV-2 variants continue to emerge, the updated XBB.1.5 monovalent vaccines remain to be evaluated in terms of immunogenicity against live clinical isolates. We report boosting of IgG(2.1X), IgA(1.5X), and total IgG/A/M(1.7X) antibodies targeting the spike receptor-binding domain and neutralizing titers against WA1(2.2X), XBB.1.5(7.4X), EG.5.1(10.5X), and JN.1(4.7X) variants.

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