Optical Control of Cardiac Electrophysiology by thePhotochromic Ligand AB2
Fehrentz, T.; Kloecker, N.; Amin, E.
Show abstract
Ventricular arrhythmias (VAs) may occur in both the structurally normal and diseased heart. Particularly, patients suffering from ischemic heart disease and heart failure are at high risk of recurrent VA eventually leading to sudden cardiac death (SCD). While high-voltage shocks delivered by an implantable defibrillator may prevent SCD, these interventions themselves impair quality of life and raise both morbidity and mortality, which accentuates the need for developing novel defibrillation techniques. Here, we report the photochromic ligand azobupivacaine 2 (AB2) to enable gradual control of cardiac electrophysiology by light. By reversibly blocking voltage-gated both Na+ and K+ channels, photoswitching of AB2 modulates both the ventricular effective refractory period and conduction velocity thereby converting VA into sinus rhythm in an ex-vivo intact heart model. Thus, AB2 opens the door to the development of an optical defibrillator based on photopharmacology.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Mitochondrial CaMKII causes metabolic reprogramming, energetic insufficiency, and dilated cardiomyopathy 92%
- A microRNA program controls the transition of cardiomyocyte hyperplasia to hypertrophy and stimulates mammalian cardiac regeneration 92%
- Single-cell transcriptome analysis reveals CD34 as a novel marker of human sinoatrial node pacemaker cardiomyocytes 92%
Similar papers in this journal
- Evidence of Superior and Inferior Sinoatrial Nodes in the Mammalian Heart 95%
- Vascular Endothelial Barrier Protection Prevents Atrial Fibrillation by Preserving Cardiac Nanostructure 95%
- Adrenergic Hypersensitivity Drives Ventricular Arrhythmias Following Loss of Plexin-Mediated Cardiac Innervation 94%
Similar papers in this journal
- Coordinated Tbx3/Tbx5 transcriptional control of the adult ventricular conduction system 93%
- Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation 93%
- Crest maturation at the cardiomyocyte surface contributes to a new late postnatal development stage that controls the diastolic function of the adult heart 92%
Similar papers in this journal
- Optical interrogation of sympathetic neuronal effects on macroscopic cardiac monolayer dynamics 94%
- Multi-parametric imaging of spatio-temporal cAMP signaling, transmembrane potential, and intracellular calcium in the Langendorff-perfused heart 94%
- Robust Small Molecule-Aided Cardiac Reprogramming Systems Selective to Cardiac Fibroblasts 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.