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Differences in polygenic associations with educational attainment between West and East Germany before and after reunification

Fraemke, D.; Willems, Y. E.; Okbay, A.; Wagner, G.; Tucker-Drob, E. M.; Harden, K. P.; Koellinger, P.; Raffington, L.

2024-03-26 genetics
10.1101/2024.03.21.585839 bioRxiv
Show abstract

Here we examine geographical and historical differences in polygenic associations with educational attainment in East and West Germany around reunification. We test this in n = 1902 25-85-year-olds from the German SOEP-G[ene] cohort. We leverage a DNA-based measure of genetic influence, a polygenic index calculated based on a previous genome-wide association study of educational attainment in individuals living in democratic countries. We find that polygenic associations with educational attainment were significantly stronger among East, but not West, Germans after but not before reunification. Negative control analyses of a polygenic index of height with educational attainment and height indicate that this gene-by-environemt interaction is specific to the educational domain. These findings suggest that the shift from an East German state-socialist to a free-market West German system increased the importance of genetic variants previously identified as important for education. One Sentence SummaryWe find that polygenic associations with educational attainment were significantly stronger among East, but not West, Germans after but not before reunification.

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