Neuroprotective Effects of Bioactive Molecules Derived from Tobacco as Potential Therapeutic Candidates for Alzheimer Disease
Liao, C.; Li, M.; Li, Z.; Wang, M.; Peng, Q.; Zhu, Z.; Wang, H.-H.; Guan, Y.
Show abstract
Neurodegenerative diseases are significant global health challenges, particularly with an aging population. While tobacco is traditionally linked to health risks, recent studies suggest it may contain compounds beneficial for neurodegenerative conditions. Herein, we explore the potential of bioactive compounds in tobacco as neuroprotective agents for Alzheimers disease (AD). Using genetic engineering, we developed a novel approach with neural progenitor cells (NPCs) derived from embryonic stem cells, equipped with an NF-{kappa}B reporter system to screen tobacco extracts. Our screenings identified three compounds with significant inhibitory effects on NF-{kappa}B activation, a key mediator of neuroinflammation in AD. Among these, rutin exhibited profound neuroprotective effects in an NPC damage model induced by Amyloid-{beta}25-35, reducing apoptotic cell death, enhancing cellular proliferation, and activating critical survival signaling pathways. This modulation underlies rutins anti-inflammatory and neuroprotective activities. Together, our findings support the potential of tobacco-derived compounds in AD therapy and lay the foundation for further exploration of their pharmaceutical value.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Thermal cycling protects SH-SY5Y cells against hydrogen peroxide and -amyloid-induced cell injury through stress response mechanisms involving Akt pathway 95%
- Allium roseum L. extract inhibits amyloid beta aggregation and toxicity involved in Alzheimers disease 95%
- Effect of high-frequency low-intensity pulsed electric field on protecting SH-SY5Y cells against hydrogen peroxide and β-amyloid-induced cell injury via ERK pathway 95%
Similar papers in this journal
- Neuroprotection in early stages of Alzheimers Disease is promoted by Transthyretin angiogenic properties 93%
- New insights into the 17β-hydroxysteroid dehydrogenase type 10 and amyloid-β 42 derived cytotoxicity relevant to Alzheimer's disease 93%
- p75 Neurotrophin Receptor Shapes the Dynamics of Adult Hippocampal Neurogenesis in Alzheimer's Disease 93%
Similar papers in this journal
- Ursolic acid inhibits cell migration and promotes JNK-dependent lysosomal associated cell death in Glioblastoma multiforme cells 92%
- Common dandelion (Taraxacum officinale) efficiently blocks the interaction between ACE2 cell surface receptor and SARS-CoV-2 spike protein D614, mutants D614G, N501Y, K417N and E484K in vitro 91%
- Rational design by structural biology of industrializable, long-acting antihyperglycemic GLP-1 receptor agonists 91%
Similar papers in this journal
Similar papers in this journal
- αS oligomers generated from polyunsaturated fatty acid and dopamine metabolite differentially interact with Aβ to enhance neurotoxicity 94%
- Glycated alpha-synuclein assemblies cause distinct Parkinsons disease pathogenesis in mice 93%
- Neurotransmitter loaded DNA nanocages as potential therapeutics for α-synuclein based neuropathies in cells and in vivo 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.