Trans-ancestral Genome Wide Association Study of Sporadic and Recurrent Miscarriage
Reynoso, A.; Nandakumar, P.; Shi, J.; Bielenberg, J.; Holmes, M. V.; Aslibekyan, S.
Show abstract
Miscarriage is a common adverse pregnancy outcome, impacting approximately 15% of pregnancies. Herein, we present results of the largest trans-ancestral genome wide association study for miscarriage to date, based on 334,593 cases of sporadic, and 52,087 cases of recurrent miscarriage in the 23andMe, Inc. Research Cohort. We identified 10 novel genome-wide significant associations for sporadic miscarriage, and one for recurrent miscarriage. These loci mapped to genes with roles in neural development and telomere length, and to developmental disorders including autism spectrum disorder. Three variants, with similar directionality and magnitude of effect, replicated in a previously published GWAS. Using Mendelian randomization and triangulation, robust evidence was found for smoking causally increasing the risk of sporadic (genetic liability to ever vs never smoking: OR 1.13; 95%CI: 1.11-1.15; P=2.61e-42) and recurrent (OR 1.25; 95%CI: 1.21-1.30; P=5.47e-34) miscarriage, with moderate, yet triangulating, evidence identified for a potential etiological role of caffeine consumption.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth 95%
- Genetic correlates of vitamin D-binding protein and 25 hydroxyvitamin D in neonatal dried blood spots 95%
- Expanding the Genetic Architecture of Nicotine Dependence and its Shared Genetics with Multiple Traits: Findings from the Nicotine Dependence GenOmics (iNDiGO) Consortium 95%
Similar papers in this journal
- Disentangling mechanisms behind the pleiotropic effects of proximal 16p11.2 BP4-5 CNVs 95%
- The impact of 22q11.2 copy number variants on human traits in the general population 94%
- Widespread recessive effects on common diseases in a cohort of 44,000 British Pakistanis and Bangladeshis with high autozygosity 94%
Similar papers in this journal
- Poison exon annotations improve the yield of clinically relevant variants in genomic diagnostic testing 91%
- Impact of prenatal exome sequencing for fetal genetic diagnosis on maternal psychological outcomes and decisional conflict in a prospective cohort 91%
- Performance of polygenic risk scores for cancer prediction in a racially diverse academic biobank 91%
Similar papers in this journal
Similar papers in this journal
- Multi-trait genome-wide association study in 34,394 Chinese women reveals the genetic architecture of plasma metabolites during pregnancy 95%
- The genetic and phenotypic correlates of neonatal Complement Component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders 94%
- Blood-based epigenome-wide analyses of chronic low-grade inflammation across diverse population cohorts 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.