5-HT1B receptors mediate dopaminergic inhibition of vesicular fusion and GABA release from striatonigral synapses.
Molinari, M.; Lieberman, O. J.; Sulzer, D.; Santini, E.; Borgkvist, A.
Show abstract
The substantia nigra pars reticulata (SNr), a crucial basal ganglia output nucleus, contains a dense expression of dopamine D1 receptors (D1Rs), along with dendrites belonging to dopaminergic neurons of substantia nigra pars compacta. These D1Rs are primarily located on the terminals of striatonigral medium spiny neurons, suggesting their involvement in the regulation of neurotransmitter release from the direct pathway in response to somatodendritic dopamine release. To explore the hypothesis that D1Rs modulate GABA release from striatonigral synapses, we conducted optical recordings of striatonigral activity and postsynaptic patch-clamp recordings from SNr neurons in the presence of dopamine and D1R agonists. We found that dopamine inhibits optogenetically triggered striatonigral GABA release by modulating vesicle fusion and Ca2+ influx in striatonigral boutons. Notably, the effect of DA was independent of D1R activity but required activation of 5-HT1B receptors. Our results suggest a serotonergic mechanism involved in the therapeutic actions of dopaminergic medications for Parkinsons disease and psychostimulant-related disorders.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Extrasynaptic NMDA receptors bidirectionally modulate intrinsic excitability of inhibitory neurons 96%
- Mu opioid receptors acutely regulate adenosine signaling in a thalamo-striatal circuit. 96%
- Dopamine release in nucleus accumbens is under tonic inhibition by adenosine A1 receptors regulated by astrocytic ENT1 and dysregulated by ethanol 95%
Similar papers in this journal
- Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice. 96%
- Sensory responses in dorsolateral striatum are modulated by motor activity in a dopamine-dependent manner 96%
- Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter 96%
Similar papers in this journal
- Selective Control of Synaptically-Connected Circuit Elements by All-Optical Synapses 96%
- Top-down acetylcholine contributes to social discrimination via enabling action potentials in olfactory bulb vasopressin cells 95%
- Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2A 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.