Role of the complement system in Long COVID
Farztdinov, V.; Zuehlke, B.; Sotzny, F.; Steinbeis, F.; Seifert, M.; Kedor, C.; Wittke, K.; Tober-Lau, P.; Textoris-Taube, K.; Ludwig, D.; Dierks, C.; Bierbaum, D.; Sander, L. E.; Hanitsch, L. G.; Witzenrath, M.; Kurth, F.; Muelleder, M.; Scheibenbogen, C.; Ralser, M.
Show abstract
Long COVID, or Post-Acute COVID Syndrome (PACS), may develop following SARS-CoV-2 infection, posing a substantial burden to society. Recently, PACS has been linked to a persistent activation of the complement system (CS), offering hope for both a diagnostic tool and targeted therapy. However, our findings indicate that, after adjusting proteomics data for age, body mass index and sex imbalances, the evidence of complement system activation disappears. Furthermore, proteomic analysis of two orthogonal cohorts--one addressing PACS following severe acute phase and another after a mild acute phase--fails to support the notion of persistent CS activation. Instead, we identify a proteomic signature indicative of either ongoing infections or sustained immune activation similar to that observed in acute COVID-19, particularly within the mild-PACS cohort.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Proteomic profiling of the large vessel vasculitis spectrum identifies shared signatures of innate immune activation and stromal remodelling 90%
- Endothelial cell-activating antibodies in COVID-19 90%
- Serum proteome analysis of systemic JIA and related pulmonary alveolar proteinosis identifies distinct inflammatory programs 90%
Similar papers in this journal
- A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis 91%
- Mass spectrometry-based quantification of proteins and post-translational modifications in dried blood: longitudinal sampling of patients with sepsis in Tanzania 90%
- Proteomic and Metabolomic Investigation of COVID-19 Patients with Elevated Serum Lactate Dehydrogenase 89%
Similar papers in this journal
- Distinct proteomic signatures in Ethiopians predict acute and long-term sequelae of COVID-19 94%
- Plasma gradient of soluble urokinase-type plasminogen activator receptor is linked to pathogenic plasma proteome and immune transcriptome and stratifies outcomes in severe COVID-19 92%
- Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients 92%
Similar papers in this journal
- Distinct lipid profile, low-level inflammation and increased antioxidant defense as a signature in HIV-1 elite control status 91%
- Peptide Ancestry Informative Markers in Uterine Neoplasms from Women of European, African and Asian Ancestry 91%
- ProteoMixture: A Cell Type Deconvolution Tool for Bulk Tissue Proteomics Data 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.