Distinct Dendritic Morphological Changes in the Nucleus Accumbens of Microbiota-deficient Male Mice
Garcia-Cabrerizo, R.; Viola, M. F.; Luczynski, P.; Clarke, G.; Cryan, J. F.
Show abstract
The gut microbiota has been shown to be an important regulator of brain and behaviour. Germ-free rodents are a key model to study the microbiome-gut-brain axis to reveal the microbial underpinnings of diseases, including those related to psychiatric illnesses. The present study evaluated whether the absence of gut microbiota could alter the morphological development of the nucleus accumbens, a brain region located in the ventral striatum involved in stress, mood and addiction. In germ-free mice, there was dendritic hypertrophy of medium spiny neurons in the shell and dendritic elongation in the core. This led to an increase in the number of stubby dendritic spines within the shell and an increase in both stubby and thin spines in the core. Taken together, these results indicate that the gut microbiota is essential for the normal development of the dendritic structure of medium spiny neurons in the nucleus accumbens and that altered remodelling may contribute to maladaptive psychiatric disorders.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- MicroRNA-210 Knockout Alters Dendritic Density and Behavioural Flexibility 93%
- Knockdown of astrocytic monocarboxylate transporter 4 (MCT4) in the motor cortex leads to loss of dendritic spines and a deficit in motor learning 93%
- Selective medial septum lesions in healthy rats induce longitudinal changes in microstructure of limbic regions, behavioral alterations, and increased susceptibility to status epilepticus 92%
Similar papers in this journal
- Dendritic Morphology and Inhibitory Regulation Distinguish Dentate Semilunar Granule Cells from Granule Cells through Distinct Stages of Postnatal Development 94%
- Characterization of basal forebrain glutamate neurons suggests a role in control of arousal and avoidance behavior 93%
- The density of doublecortin cells in the piriform cortex is affected by transition to adulthood but not first pregnancy in female mice 92%
Similar papers in this journal
- Maternal Immune Activation Alters Temporal Precision of Spike Generation of CA1 Pyramidal Neurons by Unbalancing GABAergic Inhibition in the Offspring 94%
- Early-Life Gut Inflammation Drives Sex-Dependent Shifts in the Microbiome-Endocrine-Brain Axis 93%
- Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in the rat. 92%
Similar papers in this journal
- Neurexins Regulate GABA Co-release by Dopamine Neurons 94%
- A class-specific effect of dysmyelination on the excitability of hippocampal interneurons 93%
- Microglia are Required for Developmental Specification of AgRP Innervation in the Hypothalamus of Offspring Exposed to Maternal High Fat Diet During Lactation 93%
Similar papers in this journal
- The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease 93%
- Postnatal fluoxetine treatment alters perineuronal net formation and maintenance in the hippocampus 93%
- Cellular and behavioral characterization of Pcdh19 mutant mice: subtle molecular changes, increased exploratory behavior and an impact of social environment. 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.