Villification of the intestinal epithelium is driven by Foxl1
Zhu, G.; Lahori, D.; Schug, J.; Kaestner, K.
Show abstract
The primitive gut tube of mammals initially forms as a simple cylinder consisting of the endoderm-derived, pseudostratified epithelium and the mesoderm-derived surrounding mesenchyme. During mid-gestation a dramatic transformation occurs in which the epithelium is both restructured into its final cuboidal form and simultaneously folded and refolded to create intestinal villi and intervillus regions, the incipient crypts. Here we show that the mesenchymal winged helix transcription factor Foxl1, itself induced by epithelial hedgehog signaling, controls villification by activating BMP and PDGFR as well as planar cell polarity genes in epithelial-adjacent telocyte progenitors, both directly and in a feed-forward loop with Foxo3.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A second wave of Notch signaling diversifies the intestinal secretory lineage 96%
- EHF is essential for epidermal and colonic epithelial homeostasis and suppresses Apc-initiated colonic tumorigenesis 95%
- Dynamic WT1 expression during gastrulation specifies peritoneal smooth muscle fate independently from mesothelial fate. 95%
Similar papers in this journal
- Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development 97%
- A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia 96%
- Macrophages regulate gastrointestinal motility through complement component 1q 95%
Similar papers in this journal
Similar papers in this journal
- GATA4 regulates epithelial morphogenesis in the developing mouse stomach to promote establishment of a glandular columnar epithelium 95%
- Fmo5 plays a sex-specific role in goblet cell maturation and mucus barrier formation 94%
- Enteroendocrine cells protect the stem cell niche by regulating crypt metabolism in response to nutrients 93%
Similar papers in this journal
- Jag1 modulates an oscillatory Dll1-Notch-Hes1 signaling module to coordinate growth and fate of pancreatic progenitors 94%
- Single-cell sequencing of developing human gut reveals transcriptional links to childhood Crohns disease 94%
- The mesodermal source of fibronectin is required for heart morphogenesis and cardiac outflow tract elongation by regulating cell shape, polarity, and mechanotransduction in the second heart field 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.