Spatial control of sensory adaptation modulates mechanosensing in Pseudomonas aeruginosa
Patino, R.; Kuhn, M. J.; Macmillan, H.; Inclan, Y.; Chavez, I.; Von Dollen, J.; Johnson, J. R.; Swaney, D. L.; Krogan, N.; Persat, A.; Engel, J.
Show abstract
Sensory signaling pathways use adaptation to dynamically respond to changes in their environment. Here, we report the mechanism of sensory adaptation in the Pil-Chp mechanosensory system, which the important human pathogen Pseudomonas aeruginosa uses to sense mechanical stimuli during surface exploration. Using biochemistry, genetics, and cell biology, we discovered that the enzymes responsible for adaptation, a methyltransferase and a methylesterase, are segregated to opposing cell poles as P. aeruginosa explore surfaces. By coordinating the localization of both enzymes, we found that the Pil-Chp response regulators influence local receptor methylation, the molecular basis of bacterial sensory adaptation. We propose a model in which adaptation during mechanosensing spatially resets local receptor methylation, and thus Pil-Chp signaling, to modulate the pathway outputs, which are involved in P. aeruginosa virulence. Despite decades of bacterial sensory adaptation studies, our work has uncovered an unrecognized mechanism that bacteria use to achieve adaptation to sensory stimuli.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Transient inhibition of cell division in competent pneumococcal cells results from deceleration of the septal peptidoglycan complex 97%
- A deterministic, c-di-GMP-dependent genetic program ensures the generation of phenotypically similar, symmetric daughter cells during cytokinesis 97%
- Primary role of the Tol-Pal complex in bacterial outer membrane lipid homeostasis 97%
Similar papers in this journal
- Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq 97%
- Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products 96%
- PomX, a ParA/MinD ATPase activating protein, is a triple regulator of cell division in Myxococcus xanthus 96%
Similar papers in this journal
- Spatio-temporal control of DNA replication by the pneumococcal cell cycle regulator CcrZ 97%
- A bacterial pan-genome makes gene essentiality strain-dependent and evolvable 96%
- E. coli FtsN coordinates synthesis and degradation of septal peptidoglycan by partitioning between a synthesis track and a denuded glycan track 95%
Similar papers in this journal
- Oxygen depletion and nitric oxide stimulate type IV MSHA pilus retraction in Vibrio cholerae via activation of the phosphodiesterase CdpA 96%
- Structural modeling reveals the allosteric switch controlling the chitin utilization program of Vibrio cholerae 96%
- Fluoride triggers lysis in Streptococcus mutans by inhibition of Clp protease complex leading to an unabated competence cascade 96%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.