Perinatal Brain Injury Triggers Niche-Specific Changes to Cellular Biogeography
Tahmasian, N.; Feng, M. Y.; Arbabi, K.; Rusu, B.; Cao, W.; Kukreja, B.; Lubotzky, A.; Wainberg, M.; Tripathy, S.; Kalish, B. T.
Show abstract
Preterm infants are at risk for brain injury and neurodevelopmental impairment due, in part, to white matter injury following chronic hypoxia exposure. However, the precise molecular mechanisms by which perinatal hypoxia disrupts early neurodevelopment are poorly understood. Here, we constructed a brain-wide map of the regenerative response to newborn brain injury using high-resolution imaging-based spatial transcriptomics to analyze over 1.3 million cells in a mouse model of chronic neonatal hypoxia. Additionally, we developed a new method for inferring condition-associated differences in cell type spatial proximity, enabling the identification of niche-specific changes in cellular architecture. We observed hypoxia-associated changes in region-specific cell states, cell type composition, and spatial organization. Importantly, our analysis revealed mechanisms underlying reparative neurogenesis and gliogenesis, while also nominating pathways that may impede circuit rewiring following perinatal hypoxia. Altogether, our work provides a comprehensive description of the molecular response to newborn brain injury.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Defining the molecular identity and morphology of glia limitans superficialis astrocytes in mouse and human 97%
- Microglial phagocytosis of single dying oligodendrocytes is mediated by CX3CR1 but not MERTK 95%
- Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons 95%
Similar papers in this journal
- Radial glia promote microglial development through integrin aVb8 -TGFb1 signaling 96%
- Shared inflammatory glial cell signature after brain injury, revealed by spatial, temporal and cell-type-specific profiling of the murine cerebral cortex 96%
- Microenvironment Impacts the Molecular Architecture and Interactivity of Resident Cells in Marmoset Brain 96%
Similar papers in this journal
- Spatiotemporal transcriptomic maps of mouse intracerebral hemorrhage at single-cell resolution 96%
- Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Identities from Microglia 96%
- ZBTB7A regulates MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in orbitofrontal cortex 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.