Extended blood stage sensitivity profiles of Plasmodium vivax to doxycycline and tafenoquine using Plasmodium cynomolgi as a model
Christensen, P.; Cinzah, R.; Suwanarusk, R.; Chua, A. C. Y.; Kaneko, O.; Kyle, D. E.; Aung, H. L.; Matheson, J.; Bifani, P.; Renia, L.; Cook, G. M.; Snounou, G.; Russell, B. M.
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Testing Plasmodium vivax antimicrobial sensitivity is limited to ex vivo schizont maturation assays, which precludes determining the IC50s of delayed action antimalarials such as doxycycline. Using Plasmodium cynomolgi as a model for P. vivax, we determined the physiologically significant delayed death effect induced by doxycycline (IC50(96h), 1401 {+/-} 607 nM). As expected, IC50(96 h) to chloroquine (20.4 nM), piperaquine (12.6 {micro}M) and tafenoquine (1424 nM) were not affected by extended exposure.
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