Role of PLK1 in the epigenetic maintenance of centromeres
Conti, D.; Esposito Verza, A.; Pesenti, M. E.; Cmentowski, V.; Vetter, I. R.; Pan, D.; Musacchio, A.
Show abstract
The centromere, a chromosome locus defined by the histone H3-like protein CENP-A, seeds the kinetochore to bind microtubules during cell division. Centromere maintenance requires CENP-A to be actively replenished by dedicated protein machinery in the early G1 cell-cycle phase, compensating for its two-fold dilution following DNA replication. Cyclin-dependent kinases (CDKs) limit CENP-A deposition to once per cell cycle and function as negative regulators outside early G1. Antithetically, Polo-like kinase 1 (PLK1) promotes CENP-A deposition in early G1, but the molecular details are still unknown. We reveal a phosphorylation network that recruits PLK1 to the deposition machinery to control a conformational switch required for licensing the CENP-A deposition reaction. Our findings solve the long-standing question of how PLK1 contributes to the epigenetic maintenance of centromeres. One-Sentence SummaryPLK1 licenses epigenetic maintenance of centromeres by regulating a conformational switch on the MIS18 protein.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Mitotic chromosome condensation resets chromatin to maintain transcriptional homeostasis 97%
- Molecular convergence by differential domain acquisition is a hallmark of chromosomal passenger complex evolution 96%
- A noncanonical GTPase signaling mechanism controls exit from mitosis in budding yeast 96%
Similar papers in this journal
- Epigenetic memory as a time integral over prior history of Polycomb phase separation 96%
- Unscheduled DNA replication in G1 causes genome instability through head-to-tail replication fork collisions 96%
- Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.