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A series of spontaneously blinking dyes for super-resolution microscopy

Holland, K. L.; Plutkis, S. E.; Daugird, T. A.; Sau, A.; Grimm, J. B.; English, B. P.; Zheng, Q.; Dave, S.; Rahman, F.; Xie, L.; Dong, P.; Tkachuk, A. N.; Brown, T. A.; Singer, R. H.; Liu, Z. J.; Galbraith, C. G.; Musser, S. M.; Legant, W. R.; Lavis, L. D.

2024-02-24 cell biology
10.1101/2024.02.23.581625 bioRxiv
Show abstract

Spontaneously blinking fluorophores permit the detection and localization of individual molecules without reducing buffers or caging groups, thus simplifying single-molecule localization microscopy (SMLM). The intrinsic blinking properties of such dyes are dictated by molecular structure and modulated by environment, which can limit utility. We report a series of tuned spontaneously blinking dyes with duty cycles that span two orders of magnitude, allowing facile SMLM in cells and dense biomolecular structures.

Published in Nature Methods (predicted rank #2) · training set

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