Host 5-HT affects Plasmodium transmission in mosquitoes via modulating mosquito mitochondrial homeostasis
Gao, L.; Zhang, B.; Feng, Y.; Yang, W.; Zhang, S.; Wang, J.
Show abstract
Malaria parasites hijack the metabolism of their mammalian host during the blood-stage cycle. Anopheles mosquitoes depend on mammalian blood to survive and to transmit malaria parasites. However, it remains understudied whether changes in host metabolism affect parasite transmission in mosquitoes. In this study, we discovered that Plasmodium infection significantly decreased the levels of the tryptophan metabolite, 5-hydroxytryptamine (5-HT), in both humans and mice. The reduction led to the decrease of 5-HT in mosquitoes. Oral supplementation of 5-HT to Anopheles stephensi enhanced its resistance to Plasmodium berghei infection by promoting the generation of mitochondrial reactive oxygen species. This effect was due to the accumulation of dysfunctional mitochondria caused by 5-HT-mediated inhibition of mitophagy. Elevating 5-HT levels in mouse serum significantly suppressed parasite infection in mosquitoes. In summary, our data highlight the critical role of metabolites in animal blood in determining the capacity of mosquitoes to control parasite infection.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Genetic screens reveal a central role for heme biosynthesis in artemisinin susceptibility 95%
- Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii 94%
- High-Resolution Proteomics Unveils Salivary Gland Disruption and Saliva-Hemolymph Protein Exchange in Plasmodium-Infected Mosquitoes 94%
Similar papers in this journal
- Autophagy protein Atg7 is essential and druggable for maintaining malaria parasite cellular homeostasis and organelle biogenesis 95%
- Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites 95%
- Nutrient limitation mimics artemisinin tolerance in malaria 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.