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Differential connectivity of frontolimbic circuit induced by individualized disorder-specific stimuli in distinct symptom profiles of obsessive-compulsive disorder

2024-02-18 psychiatry and clinical psychology Title + abstract only
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BackgroundEmotional processing deficits in obsessive-compulsive disorder (OCD) are reportedly caused by an aberrant frontolimbic circuit activation with inconsistent evidence, possibly due to symptom heterogeneity. We compared the activation and connectivity patterns of the frontolimbic structures during symptom provocation between patients with distinct symptom profiles of OCD. MethodsWe recruited 37 symptomatic OCD subjects categorized based on predominant symptom profiles, i.e., 19 with cont...

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