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External validation of Finnish Diabetes Risk Score (FINDRISC) and Latin American FINDRISC for screening of undiagnosed dysglycemia: analysis in a Peruvian hospital health care workers sample.

Yovera-Aldana, M.; Mezones-Holguin, E.; Agüero-Zamora, R.; Damas-Casani, L.; Uriol-Llanos, B.; Espinoza-Morales, F.; Soto-Becerra, P.; Ticse-Aguirre, R.

2024-02-18 endocrinology
10.1101/2024.02.16.24302929 medRxiv
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AimsTo evaluate the external validity of Finnish diabetes risk score (FINDRISC) and Latin American FINDRISC (LAFINDRISC) for undiagnosed dysglycemia in hospital health care workers. MethodsWe carried out a cross-sectional study on health workers without a prior history of diabetes mellitus (DM). Undiagnosed dysglycemia (prediabetes or diabetes mellitus) was defined using fasting glucose and two-hour oral glucose tolerance test. LAFINDRISC is an adapted version of FINDRISC with different waist circumference cut-off points. We calculated the area under the receptor operational characteristic curve (AUROC) and explored the best cut-off point. ResultsWe included 549 participants in the analysis. The frequency of undiagnosed dysglycemia was 17.8%. The AUROC of LAFINDRISC and FINDRISC were 71.5% and 69.2%; p=0.007, respectively. The optimal cut-off for undiagnosed dysglycemiaaccording to Index Youden was [≥] 11 in LAFINDRISC (Sensitivity: 78.6%; Specificity: 51.7%) and [≥]12 in FINDRISC (Sensitivity: 70.4%; Specificity: 53.9%) ConclusionThe discriminative capacity of both questionnaires is good for the diagnosis of dysglycemia in the healthcare personnel of the Maria Auxiliadora hospital. The LAFINDRISC presented a small statistical difference, nontheless clinically similar, since there was no difference by age or sex. Further studies in the general population are required to validate these results.

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