The regulatory network of the White Collar complex during early mushroom development in Schizophyllum commune
Vonk, P. J.; Van der Poel, M. J. P.; Niemeijer, Z. E.; Ohm, R. A.
Show abstract
Blue light is an important signal for fungal development and is detected by the White Collar complex, which consists of WC-1 and WC-2. Most of our knowledge on this complex is derived from the ascomycete Neurospora crassa, where both WC-1 and WC-2 contain GATA zinc-finger transcription factor domains. In basidiomycetes, WC-1 is truncated and does not contain a transcription factor domain, but both WC-1 and WC-2 are still important for development . In the model mushroom Schizophyllum commune, we show that dimerization of WC-1 and WC-2 happens independent of light, but that induction by light is required for promoter binding by the White Collar complex. Furthermore, the White Collar complex is a promoter of transcription, but binding of the complex alone is not always sufficient to initiate transcription. For its function, the White Collar complex associates directly with the promoters of structural genes involved in mushroom development, like hydrophobins, but also promotes the expression of other transcription factors that play a role in mushroom development.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Phosphatidic acid produced by phospholipase D is required for hyphal cell-cell fusion and fungal-plant symbiosis 96%
- An amino-terminal threonine/serine motif is necessary for activity of the Crp/Fnr homolog, MrpC, and for Myxococcus xanthus developmental robustness 95%
- High-throughput transposon sequencing highlights the cell wall as an important barrier for osmotic stress in methicillin resistant Staphylococcus aureus and underlines a tailored response to different osmotic stressors 94%
Similar papers in this journal
Similar papers in this journal
- Ferric reductase-related proteins mediate fungal heme acquisition 95%
- Hülle-cell-mediated protection of fungal reproductive and overwintering structures against fungivorous animals 95%
- Obligate sexual reproduction of a homothallic fungus closely related to the Cryptococcus pathogenic species complex 95%
Similar papers in this journal
- A synthetic genetic array screen for interactions with the RNA helicase DED1 during cell stress in budding yeast 95%
- Development and applications of a CRISPR activation system for facile genetic overexpression in Candida albicans 93%
- Characterization of the Doublesex/MAB-3 transcription factor DMD-9 in Caenorhabditis elegans 92%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.