Transcriptome analysis of the tardigrade Hypsibius exemplaris exposed to the DNA-damaging agent bleomycin
Yoshida, Y.; Hirayama, A.; Arakawa, K.
Show abstract
Tardigrades are microscopic animals that are renowned for their capabilities of tolerating near-complete desiccation by entering an ametabolic state called anhydrobiosis. However, many species also show high tolerance against radiation in the active state as well, suggesting cross-tolerance via the anhydrobiosis mechanism. Previous studies utilized indirect DNA damaging agents to identify core components of the cross-tolerance machinery; however, it was difficult to distinguish whether transcriptomic changes were the result of DNA damage or residual oxidative stress. To this end, we performed transcriptome analysis on bleomycin-exposed Hypsibius exemplaris. We observed induction of several tardigrade-specific gene families that may be the core components of the cross-tolerance mechanism. We also identified an enrichment of the tryptophan metabolism pathway, which metabolomic analysis suggested the engagement of this pathway in stress tolerance. These results provide several candidates for the core component of the cross-tolerance, as well as possible anhydrobiosis machinery.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Metabolic exchange and energetic coupling between nutritionally stressed bacterial species, the possible role of QS molecules 94%
- Quorum sensing mediates morphology and motility transitions in the model archaeon Haloferax volcanii 94%
- Uncovering the temporal dynamics and regulatory networks of thermal stress response in a hyperthermophile using transcriptomics and proteomics 94%
Similar papers in this journal
- Quorum-sensing gene regulates hormetic effects induced by sulfonamides in Comamonadaceae 95%
- High Enzyme Promiscuity in Lignin Degradation Mechanisms in Rhodopseudomonas palustris CGA009 95%
- Transcriptomic profiling of Debaryomyces hansenii reveals detoxification and stress responses to benzo(a)pyrene exposure 94%
Similar papers in this journal
Similar papers in this journal
- Lifespan prolonging mechanisms and insulin upregulation without fat accumulation in long-lived reproductives of a higher termite 94%
- Systems-wide Analysis Revealed Shared and Unique Responses to Moderate and Acute High Temperatures in the Green Alga Chlamydomonas reinhardtii 93%
- Targeted biomass degradation by the higher termite gut system - integrative omics applied to host and its gut microbiome 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.