Task Activation Results in Regional 13C-Lactate Signal Increase in the Human Brain
Uthayakumar, B.; Cappelletto, N. I. C.; Bragagnolo, N. D.; Chen, A. P.; Ma, N.; Perks, W. J.; Endre, R.; Tam, F.; Graham, S. J.; Heyn, C.; Keshari, K. R.; Soliman, H.; Cunningham, C. H.
Show abstract
Hyperpolarized-13C magnetic resonance imaging (HP-13C MRI) was used to image changes in 13C-lactate signal during a visual stimulus condition in comparison to an eyes-closed control condition. Whole-brain 13C-pyruvate, 13C-lactate and 13C-bicarbonate production was imaged in healthy volunteers (N=6, ages 24-33) for the two conditions using two separate hyperpolarized 13C-pyruvate injections. BOLD-fMRI scans were used to delineate regions of functional activation. 13C-metabolite signal was normalized by 13C-metabolite signal from the brainstem and the percentage change in 13C-metabolite signal conditions was calculated. A one-way Wilcoxon signed-rank test showed a significant increase in 13C-lactate in regions of activation when compared to the remainder of the brain (p = 0.02, V = 21). No significant increase was observed in 13C-pyruvate (p = 0.11, V = 17) or 13C-bicarbonate (p = 0.95, V = 3) signal. The results show an increase in 13C-lactate production in the activated region that is measurable with HP-13C MRI.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Increased Brain Volumetric Measurement Precision from Multi-Site 3D T1-weighted 3T Magnetic Resonance Imaging by Correcting Geometric Distortions 95%
- Noise decorrelation optimizes SNR of GABA-edited MRS data: A comparison of RF coil combination methods 93%
- Tailored Magnetic Resonance Fingerprinting 93%
Similar papers in this journal
- Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct ( 2 H) and indirect ( 1 H) detection of deuterium labeled compounds at 7T and clinical 3T 96%
- Deuterium metabolic imaging and hyperpolarized 13 C-MRI of the normal human brain at clinical field strength reveals differential cerebral metabolism 96%
- The potential for gas-free measurements of absolute oxygen metabolism during both baseline and activation states in the human brain 95%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.