Manipulation of the Nuclear Envelope-Associated Protein SLAPDuring Mammalian Brain Development Affects Cortical Lamination and Exploratory Behavior
Mestres, I.; Atabay, A.; Escolano, J.-C.; Arndt, S.; Schmidtke, K.; Einsiedel, M.; Patsonis, M.; Castro, L. A.; Yun, M.; Bernhardt, N.; Taubenberger, A. V.; Calegari, F.
Show abstract
Here we report the first characterization of the effects resulting from the manipulation of Soluble-Lamin Associated Protein (SLAP) expression during mammalian brain development. We found that SLAP localizes to the nuclear envelope and when overexpressed causes changes in nuclear morphology and lengthening of mitosis. SLAP overexpression in apical progenitors of the developing mouse brain altered asymmetric cell division, neurogenic commitment and neuronal migration ultimately resulting in unbalance in the proportion of upper, relative to deeper, neuronal layers. Several of these effects were also recapitulated upon Cas9-mediated knock-down. Ultimately, SLAP overexpression during development resulted in a reduction in subcortical projections of young mice and, notably, reduced their exploratory behavior. Our study shows the potential relevance of the previously uncharacterized nuclear envelope protein SLAP in neurodevelopmental disorders.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Extracellular matrix-inducing Sox9 orchestrates basal progenitor proliferation and gliogenesis in developing neocortex 96%
- The ciliary kinesin KIF7 controls the development of the cerebral cortex by acting differentially on SHH-signaling in dorsal and ventral forebrain 96%
- SNARE protein tomosyn regulates dense core vesicle composition but not exocytosis in mammalian neurons 96%
Similar papers in this journal
- Breasi-CRISPR: an efficient genome editing method to interrogate protein localization and protein-protein interactions in the embryonic mouse cortex 97%
- Bidirectional interaction between Protocadherin 8 and transcription factor Dbx1 regulates cerebral cortex development 96%
- The BMP antagonist Gremlin1 contributes to the development of cortical excitatory neurons, motor balance and fear responses 96%
Similar papers in this journal
- Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum 95%
- Silc1 long noncoding RNA is an immediate-early gene promoting efficient memory formation 95%
- Mitochondrial dysfunction impairs human neuronal development and reduces neuronal network activity and synchronicity 95%
Similar papers in this journal
- A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation 96%
- Temporal constraints on enhancer usage shape the regulation of limb gene transcription 95%
- KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors 95%
Similar papers in this journal
- CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling 96%
- LTK and ALK regulate neuronal polarity and cortical migration by modulating IGF1R activity 96%
- Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.