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Phase II Randomized Study of Short Course Radiotherapy Total Neo-adjuvant Therapy with or without Chlorophyllin in Reducing the Incidence of >/=Grade 2 Acute Toxicity in Advanced Rectal Cancer patients Suitable for Wait and Watch
2024-01-28
oncology
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BackgroundTotal Neoadjuvant treatment (TNT) comprising short-course radiotherapy (SCRT) and induction chemotherapy is one of the standard treatment options for locally advanced rectal cancer (LARC). The addition of localised radiotherapy boost dose using techniques such as brachytherapy can improve local tumour control and organ preservation, in selected good responder patients. Overall increased risk of acute treatment-related toxicity rates with TNT approaches can be a deterrent to compliance,...
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