Harnessing Stress: balancing the Burden of Slightly-Deleterious Variants by a Handicap
Shamanskiy, V. A.; Popadin, K. Y.
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Numerous empirical studies have revealed epistatic interactions among deleterious variants. In this paper, we assume such interactions are widespread and analyze the resulting shift in mutational burden and average population fitness following the introduction of a strong and universal stress (hereafter "handicap"). We demonstrate that organisms with a low burden of slightly-deleterious variants (SDVs) are more likely to survive exposure to a handicap, whether genetic or environmental, leading to a purifying effect on the population. We further discuss the potential applications of harnessing such interactions for evolutionary and population studies as well as for population management.
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