Crosstalk between the RNA-binding proteins Regnase-1 and -3 shapes mast cell survival and cytokine expression
Bataclan, M.; Leoni, C.; Moro, S. G.; Pecoraro, M.; Wong, E. H.; Heissmeyer, V.; Monticelli, S.
Show abstract
Post-transcriptional regulation of immune-related transcripts by RNA-binding proteins (RBPs) impacts immune cell responses, including mast cell functionality. Despite their importance in immune regulation, the functional role of most RBPs remains to be understood. By manipulating the expression of specific RBPs in mast cells, coupled with mass spectrometry and transcriptomic analyses, we found that the Regnase family of proteins acts as a potent regulator of mast cell physiology. Specifically, Regnase-1 is required to maintain basic cell proliferation and survival, while both Regnase-1 and -3 cooperatively regulate the expression of inflammatory transcripts upon mast cell activation, with Tnf being a primary target of both proteins. In mast cells, Regnase-3 directly interacts with Regnase-1 and is necessary to restrain Regnase-1 expression through the destabilization of its transcript. Overall, our study identifies protein interactors of endogenously expressed Regnase factors, characterizes the regulatory interplay between Regnase family members in mast cells, and establishes their role in the control of mast cell homeostasis and inflammatory responses.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Mitochondrial respiration contributes to the interferon gamma response in antigen presenting cells 96%
- A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation 96%
- NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in Solitary Fibrous Tumors 95%
Similar papers in this journal
- The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair 96%
- Predictive framework of macrophage activation 95%
- Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells. 95%
Similar papers in this journal
- Characterizing control of memory CD8 T cell differentiation by BTB-ZF transcription factor Zbtb20 95%
- Identification of a novel enhancer essential for Satb1 expression in TH2 cells and activated ILC2s. 94%
- The ADAM17 sheddase complex regulator iTAP modulates inflammation, epithelial repair, and tumor growth 94%
Similar papers in this journal
- Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism 96%
- Ki-67 promotes sequential stages of tumourigenesis by enabling cellular plasticity 95%
- T Lymphocyte-Specific Deletion of SHP1 and SHP2 Promotes Activation-Induced Cell Death of CD4+ T Cells and Impairs Antitumor Response 95%
Similar papers in this journal
- Integrated signaling and transcriptome analysis reveals Src-family kinase individualities and novel pathways controlled by their constitutive activity 95%
- Single cell transcriptomics reveals cell type specific features of developmentally regulated responses to lipopolysaccharide between birth and 5 years. 95%
- Chromatin Changes Associated with Neutrophil Extracellular Trap (NET) Formation in Whole Blood Reflect Complex Immune Signaling 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.