GABAB- GluK1 kainate receptor interplay modulates amygdala excitability and behavioral response to chronic stress
Ryazantseva, M.; Liiwand, M.; Lauri, S.
Show abstract
Amygdala hyperexcitability is a hallmark for stress-induced anxiety disorders. Stress-associated changes in both principal neurons and interneurons contribute to the increased excitability, but how exactly these mechanisms perturb function of behaviorally relevant circuits in the amygdala remains unclear. Here, we show that GluK1 subunit-containing kainate receptors in parvalbumin (PV) interneurons maintain high GABA release and control excitability of lateral amygdala (LA) principal neurons via tonic GABAB-receptor-mediated inhibition. Downregulation of GluK1 expression in PV interneurons after chronic restraint stress (CRS) releases the tonic inhibition and increases excitability of LA principal neurons. Stress-induced LA hyperexcitability facilitates glutamatergic transmission selectively to central amygdala PKC{delta}-expressing neurons, implicated in fear generalization. Consistent with significance in anxiogenesis, absence of GluK1- GABAB regulation confers resilience against CRS-induced LA hyperexcitability and anxiety-like behavior. Our data reveal a unique novel mechanism involving an interplay between glutamatergic and GABAergic systems in the regulation of amygdala excitability in response to chronic stress.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Contribution of NPY Y5 Receptors to the Reversible Structural Remodeling Of Basolateral Amygdala Dendrites in Male Rats Associated with NPY-mediated Stress Resilience. 97%
- Basal G-protein-gated inwardly rectifying potassium (Kir3/GirK) channels activity governs synaptic plasticity that supports dorsal hippocampus-dependent cognitive functions 96%
- Total number and ratio of GABAergic neuron types in the mouse lateral and basal amygdala 96%
Similar papers in this journal
- Choosing memory retrieval strategies: a critical role for inhibition in the dentate gyrus 96%
- High emotional reactivity is associated with activation of a molecularly distinct hippocampal-amygdala circuit modulated by the glucocorticoid receptor 96%
- Early life stress induced sex-specific changes in behavior is paralleled by altered locus coeruleus physiology in BALB/cJ mice 95%
Similar papers in this journal
- LTD at amygdalocortical synapses as a novel mechanism for hedonic learning 96%
- Generation and validation of a CRF1:Cre transgenic rat: The role of central amygdala CRF1 in nociception and anxiety-like behavior 96%
- VTA-projecting cerebellar neurons mediate stress-dependent depression-like behavior 95%
Similar papers in this journal
- Synaptic communication within the microcircuits of pyramidal neurons and basket cells in the mouse prefrontal cortex 96%
- Cation-chloride cotransporters and the polarity of GABA signaling in mouse hippocampal parvalbumin interneurons 95%
- Inhibitory actions of melanin-concentrating hormone in the lateral septum 95%
Similar papers in this journal
- Excitatory synaptic transmission is differentially modulated by opioid receptors along the claustro-cingulate pathway 95%
- Dopamine D2 receptors modulate intrinsic properties and synaptic transmission of parvalbumin interneurons in the mouse primary motor cortex 95%
- Cell-type specificity of neuronal excitability and morphology in the central amygdala 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.