Targeting ductal-endothelial crosstalk alleviate pancreatitis
Gao, R.-r.; Ma, L.-y.; Chen, J.-w.; Wang, Y.-x.; Li, Y.-y.; Zhou, Z.-y.; Deng, Z.-h.; Zhong, J.; Shu, Y.-h.; Liu, Y.; Chen, Q.
Show abstract
Pancreatitis are common gastrointestinal disorders that cause hospitalization with significant morbidity and mortality. The mechanistic pathophysiology of pancreatitis is complicated, which greatly limits the discovery of pharmacological intervention methods. Here, we show that administration of antagonist of Integrin-5, significantly mitigates the pathological condition of acute pancreatitis. In caerulein-induced acute pancreatitis model, the newly emergent CK19 positive cells are highly vascularized with significant increase of vascular density and endothelial cell number. Single cell RNA sequencing analysis shows ductal and endothelial cells are intimate interacting partners. Pancreatitis dramatically reduce the crosstalk in ductal-endothelial interface but promote the integrin-5 signaling. Blocking this signaling significantly reduce acinar-to-ductal metaplasia, pathological angiogenesis and restore other abnormal defects induced by caerulein. Our work reveals a therapeutic potential of targeting integrin-5 as uncharacterized pharmacological method to alleviate the symptom of pancreatitis.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Single cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree 95%
- Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells 94%
- Single cell transcriptome analysis of cavernous tissues reveals the key roles of pericytes in diabetic erectile dysfunction 94%
Similar papers in this journal
- Deficient ER acetyl-CoA import in acinar cells leads to chronic pancreatitis 94%
- The Stmn1-lineage contributes to acinar regeneration but not to neoplasia upon oncogenic Kras expression 94%
- Loss of intestinal endosome associated protein sorting nexin 27 disrupts epithelial barrier and promotes inflammation 93%
Similar papers in this journal
- PI3Kγ promotes neutrophil extracellular trap formation by noncanonical pyroptosis in abdominal aortic aneurysm 95%
- Ddr1-Induced Neutrophil Extracellular Traps Drive Pancreatic Cancer Metastasis 93%
- Microfluidic Device Facilitates Novel In Vitro Modeling of Human Neonatal Necrotizing Enterocolitis-on-a-Chip 93%
Similar papers in this journal
- CD73 generated extracellular adenosine promotes resolution of neutrophil-mediated tissue injury and restrains metaplasia in pancreatitis 96%
- Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating PPARγ-UCP2 cascade 92%
- Spatial mapping of dextran sodium sulphate-induced intestinal inflammation and its systemic effects 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.