The triose phosphate/phosphate translocator exports photosynthetic glyceraldehyde 3-phosphate from chloroplasts to trigger antimicrobial immunity in plants.
Zuo, D.-P.; Wang, B.; Liu, Y.-Z.; Chen, Z.-S.; Hu, R.-J.; He, M.-J.; Zhang, Z.-Y.; Wang, Y.; Han, C.-G.
Show abstract
Chloroplasts play a crucial role in plant immunity against invading microbes. However, it remains poorly understood whether photosynthetic metabolites from chloroplasts participate directly in host defenses. Here, we uncovered Arabidopsis thalinana triose phosphate/phosphate translocator (AtTPT), a known translocator for chloroplast inner membrane, plays an indispensable role in suppressing virus infection and evoking defense responses. Interestingly, overexpression of AtTPT impairs virus accumulation in plants, while loss-of-function tpt3 mutants exhibit an increased viral load. The antiviral activity of AtTPT requires its phosphate transport capacity, implying that it actually functions through its metabolite(s). To this end, we found that glyceraldehyde 3-phosphate (GAP), one of AtTPTs translocated metabolites, can drastically enhance expression of defense-related genes and prominently induce defense signaling pathways. More excitingly, AtTPT or GAP robustly restricts the proliferation of multiple types of phytopathogens. Collectively, we propose that AtTPT exports GAP to mediate broad-spectrum resistance to pathogens, which provides new insights into the mechanism underlying the chloroplast-mediated immunity by a photosynthetic metabolite.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Emergence of isochorismate-based salicylic acid biosynthesis within Brassicales 96%
- Pangenomics facilitated with structural analysis reveals host NAD+ manipulation as a major virulence activity of bacterial effectors 95%
- THESEUS1 modulates cell wall stiffness and abscisic acid production in Arabidopsis thaliana 95%
Similar papers in this journal
- A SUMO interacting motif in the Replication initiator protein of Tomato yellow leaf curl virus is required for viral replication 95%
- Functionality of potato virus Y coat protein in cell-to-cell movement is defined by its N terminal region 94%
- Development of a mini-replicon-based reverse-genetics system for rice stripe tenuivirus 93%
Similar papers in this journal
Similar papers in this journal
- Cyclic-di-GMP controls Type III effector export and symptom development in Pseudomonas syringae infections via the export ATPase HrcN 95%
- Regressive evolution of an effector following a host jump in the Irish Potato Famine Pathogen Lineage 94%
- Mobilization of nuclear antiviral factors by Exportin XPO1 via the actin network inhibits RNA virus replication 94%
Similar papers in this journal
- Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity 96%
- Vascular fungi alter the apoplastic purinergic signaling in plants by deregulating the homeostasis of extracellular ATP and its metabolite adenosine 94%
- Tetraose steroidal glycoalkaloids from potato provide resistance against Alternaria solani and Colorado potato beetle 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.