Back

mixWAS: An efficient distributed algorithm for mixed-outcomes genome-wide association studies

2024-01-10 genetic and genomic medicine Title + abstract only
View on medRxiv
Show abstract

In cross-cohort studies, integrating diverse datasets, such as electronic health records (EHRs), is both essential and challenging due to cohort-specific variations, distributed data storage, and data privacy concerns. Traditional methods often require data pooling or complex data harmonization, which can reduce efficiency and limit the scope of cross-cohort learning. We introduce mixWAS, a one-shot, lossless algorithm that efficiently integrates distributed EHR datasets via summary statistics. ...

Predicted journal destinations

1
Nature Communications
483 training papers
Top 3% 17.3%
2
Bioinformatics
24 training papers
#1 14.3%
3
The American Journal of Human Genetics
77 training papers
Top 1% 11.5%
4
Nature Genetics
72 training papers
Top 1% 7.6%
5
Scientific Reports
701 training papers
Top 40% 6.3%
6
Genome Medicine
56 training papers
Top 2% 5.8%
7
Cell Genomics
34 training papers
Top 0.7% 3.8%
8
Genetics in Medicine
57 training papers
Top 4% 3.8%
9
PLOS Genetics
39 training papers
Top 0.9% 3.8%
10
Human Genetics and Genomics Advances
39 training papers
Top 3% 2.1%
11
Proceedings of the National Academy of Sciences
100 training papers
Top 9% 1.5%
12
Human Molecular Genetics
28 training papers
Top 3% 1.5%
13
eLife
262 training papers
Top 30% 1.5%
14
European Journal of Human Genetics
25 training papers
Top 3% 1.5%
15
PLOS ONE
1737 training papers
Top 96% 1.3%
16
Nature
58 training papers
Top 6% 1.1%
17
PLOS Computational Biology
141 training papers
Top 12% 0.9%
18
npj Digital Medicine
85 training papers
Top 18% 0.9%
19
Frontiers in Genetics
32 training papers
Top 7% 0.9%
20
Circulation: Genomic and Precision Medicine
30 training papers
Top 7% 0.7%
21
Communications Biology
36 training papers
Top 6% 0.7%
22
Genes
21 training papers
Top 5% 0.7%
23
Nature Medicine
88 training papers
Top 19% 0.7%
24
Science Advances
52 training papers
Top 6% 0.7%
25
npj Genomic Medicine
18 training papers
Top 6% 0.7%