GABA Increases Sensory Transmission In Monkeys
Mahrous, A. A.; Liang, L.; Balaguer, J.-M.; Ho, J. C.; Hari, K.; Grigsby, E. M.; Karapetyan, V.; Damiani, A.; Fields, D. P.; Gonzalez-Martinez, J. A.; Gerszten, P. C.; Bennett, D. J.; Heckman, C. J.; Pirondini, E.; Capogrosso, M.
Show abstract
Sensory input flow is central to voluntary movements. For almost a century, GABA was believed to modulate this flow by inhibiting sensory axons in the spinal cord to sculpt neural inputs into skilled motor output. Instead, here we show that GABA can also facilitate sensory transmission in monkeys and consequently increase spinal and cortical neural responses to sensory inputs challenging our understanding of generation and perception of movement.
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