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ROS-induced translational regulation--through spatiotemporal differences in codon recognition--is a key driver of brown adipogenesis

Ip, J. Y.; Wijaya, I.; Lee, L. T.; Lim, Y.; Teoh, D. E.-J.; Chan, C. S. C.; Cui, L.; Begley, T. J.; Dedon, P. C.; Guo, H.

2023-12-23 molecular biology
10.1101/2023.12.22.572954 bioRxiv
Show abstract

The role of translational regulation in brown adipogenesis is relatively unknown. Localized translation of mRNAs encoding mitochondrial components enables swift mitochondrial responses, but whether this occurs during brown adipogenesis, which involves massive mitochondrial biogenesis, has not been explored. Here, we used ribosome profiling and RNA-Seq, coupled with cellular fractionation, to obtain spatiotemporal insights into translational regulation. During brown adipogenesis, a translation bias towards G/C-ending codons is triggered first in the mitochondrial vicinity by reactive oxygen species (ROS), which later spreads to the rest of the cell. This translation bias is induced through ROS modulating the activity of the tRNA modification enzyme, ELP3. Intriguingly, functionally relevant mRNAs, including those encoding ROS scavengers, benefit from this bias; in so doing, ROS-induced translation bias both fuels differentiation and concurrently minimizes oxidative damage. These ROS-induced changes could enable sustained mitochondrial biogenesis during brown adipogenesis, and explain in part, the molecular basis for ROS hormesis.

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