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Immunogenicity, reactogenicity, and IgE-mediated immune responses of a mixed whole-cell and acellular pertussis vaccine schedule in Australian infants: a randomised, double-blind, non-inferiority trial
2023-12-22
pediatrics
Title + abstract only
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BackgroundIn most high-income countries, infant vaccination with acellular pertussis (aP) vaccines is the standard of care for the prevention of pertussis disease. Based on immunological and epidemiological evidence, we hypothesised that substitution of the first aP dose in the vaccination schedule with whole-cell (wP) vaccine might protect against the development of IgE-mediated food allergy. Here we report the results of a randomised comparison of the reactogenicity, immunogenicity, and IgE-me...
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