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Causal association of the brain structure with the risk of knee osteoarthritis: A large-scale genetic correlation study
2023-12-30
orthopedics
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ObjectivesObservational studies have shown the association between knee osteoarthritis (KOA) and neurological disorders with alterations in brain imaging-derived phenotypes (BIDPs). This study aimed at investigating whether alterations in brain structure are correlated with the occurrence of KOA. MethodsBased on the summary data from two large scale genome-wide association studies (GWASs), we performed a bidirectional two-sample Mendelian randomization (MR) analysis using single-nucleotide poly...
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