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J chain dictates the recognition of IgA by FcRL4

Su, C.; Wang, Y.; Yang, X.; Xiao, J.

2023-12-18 biochemistry
10.1101/2023.12.18.572144 bioRxiv
Show abstract

Fc-receptor-like 4 (FcRL4) selectively recognizes systemic IgA. The cryo-electron microscopy structure of the FcRL4-Fc (IgA-Fc)-Joining (J) chain complex reveals that FcRL4 interacts with Fc-J in a 1:1 stoichiometry, with FcRL4 primarily interacting with the J chain. The binding of Fc-J to FcRL4 would hinder the binding of pIgR, but not FcRI. These findings provide new insights into IgA and emphasize significant differences between various IgA receptors.

Published in Proceedings of the National Academy of Sciences (predicted rank #5) · training set

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