Syncytia Formation Promotes Virus Resistance to Interferon and Neutralizing Antibodies
Li, T.; Kang, I.; Hu, Z.; Gibbs, J.; Ye, C.; Kosik, I.; Shi, G.; Holly, J.; Kosikova, M.; Compton, A. A.; Martinez-Sobrido, L.; Johnson, R.; Hang, X.; Yewdell, J. W.
Show abstract
SARS-CoV-2, like many viruses, generates syncytia. Using SARS-CoV-2 and S (S) expressing recombinant vesicular stomatitis and influenza A viruses, we show that S-mediated syncytia formation provides resistance to interferons in cultured cells, human small airway-derived air-liquid interface cultures and hACE2 transgenic mice. Amino acid substitutions that modulate fusogenicity in Delta- and Omicron-derived S have parallel effects on viral interferon resistance. Syncytia formation also decreases antibody virus neutralization activity in cultured cells. These findings explain the continued selection of fusogenic variants during SARS-CoV-2 evolution in humans and, more generally, the evolution of fusogenic viruses despite the adverse effects of syncytia formation on viral replication in the absence of innate or adaptive immune pressure.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions 98%
- A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models 98%
- Spatial and functional arrangement of Ebola virus polymerase inside phase-separated viral factories 98%
Similar papers in this journal
- Distinct pathway for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses 97%
- Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses 96%
- {-}{-}{-}{-}{-}{-}{-}{-}RNA structures within Venezuelan equine encephalitis virus E1 alter macrophage replication fitness and contribute to viral emergence 96%
Similar papers in this journal
- CRISPR with Transcriptional Readout reveals influenza transcriptionis modulated by NELF and can precipitate an interferon response 97%
- Mechanistic Insights into Dengue Virus Inhibition by a Clinical Trial Compound NITD-688 97%
- Whole Virion Proteomics of HCMV Reveals that gpUL141 is a Virion Component that Regulates Envelope Glycoprotein Composition to Protect Against Humoral Immunity 96%
Similar papers in this journal
- A morphological transformation in respiratory syncytial virus leads to enhanced complement activation 97%
- Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies 97%
- Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies 96%
Similar papers in this journal
- Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant 98%
- Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination 96%
- Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.