snPATHO-seq: unlocking the pathology archives
Wang, T.; Harvey, K.; Escudero Morales, J.; Kiedik, B.; Al-Eryani, G.; Greenwald, A. C.; Kalavros, N.; SegatovDezem, F.; Ma, Y.; Pita-Juarez, Y.; Wise, K.; Degletagne, C.; Elz, A.; Johanneson, J.; Pakiam, F.; Ryu, H.; Newell, E. W.; Tonon, L.; Kohlway, A.; Drennon, T.; Hadadianpour, A.; Abousoud, J.; Scott, R.; Lund, P.; Durruthy, J.; Vallejos, A. F.; Kaczorowski, D.; Warren, J.; Butler, L. M.; O'Toole, S.; Plummer, J. T.; Vlachos, I.; Lundeberg, J.; Swarbrick, A.; Martelotto, L. G.
Show abstract
Formalin-fixed paraffin-embedded (FFPE) samples are valuable but underutilized in single-cell omics research due to their low DNA and RNA quality. In this study, leveraging recent single-cell genomic technology advances, we introduce a versatile method to derive high-quality single-nucleus transcriptomic data from FFPE samples.
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