Digital breast tomosynthesis(DBT) vs 2D mammography and impact of combined use: A meta-analysis

BackgroundHaving breast cancer and receiving treatment for it is viewed as a very traumatic experience for women. From the recent advances in breast cancer diagnosis protocol; The triple assessment for a lump in the breast is the best practice and its application towards early disease detection is crucial. For which, 2D mammography is used. The limitation of this technique is a potential tissue overlap in dense breasts. Digital breast tomosynthesis (DBT) is a new imaging technology that can address the limitations of 2D mammography. This study aims to highlight the use of DBT. MethodsThe study population included all women aged from 18 to 80. For this analysis, the subdivision of the population is not created. A total of 28 RCTs with a total of 1,735,126 patients were selected for the DBT+FFDM vs FFDM study and 5 RCTs with a total of 554,419 patients were selected for the DBT vs FFDM study. ResultsFor the DBT+FFDM vs FFDM; The overall diagnostic odds ratio was 1.28 with a 95%CI [1.22-1.33], the Decrease in RR is 2.43% and the increase in CDR is 1.583. for DBT vs FFDM; the overall diagnostic odds ratio was 1.38 with a 95%CI [1.28-1.50], a decrease in RR is 1.70%, and an increase in CDR is 1.4. ConclusionDBT+FFDM and DBT do outweigh FFDM alone.