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Nanoscale photobiotinylation, pulldown and sequencing of region-specific DNA from intact cells.

Zipfel, W.; Roberts, T.; Kushner, M.; Crowley, J. C.; Ozer, A.; Wang, J.; Ray, J.; Lis, J. T.

2023-12-06 genomics
10.1101/2023.12.04.569951 bioRxiv
Show abstract

Femto-seq is a novel nanoscale optical method that can be used to obtain DNA sequence information from targeted regions around a specific locus or other nuclear regions of interest. Two-photon excitation is used to photobiotinylate femtoliter volumes of chromatin within the nucleus, allowing for subsequent isolation and sequencing of DNA, and bioinformatic mapping of any nuclear region of interest in a select set of cells from a heterogenous population.

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The top 3 journals account for 50% of the predicted probability mass.

1
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8
Proceedings of the National Academy of Sciences
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Top 23%
2.2%
9
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Top 3%
1.8%
10
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1.2%
11
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1.2%
12
Science Advances
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13
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14
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15
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17
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19
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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.