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Immune profiling of COVID-19 vaccine responses in people with multiple sclerosis on B cell-depleting therapy
2023-12-05
neurology
Title + abstract only
View on medRxiv
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Background and ObjectivePeople with multiple sclerosis (pwMS) receiving B cell-depleting therapies have impaired antibody responses to vaccination. In a proportion of individuals, repeat vaccination against COVID-19 leads to seroconversion. We sought to describe the immune phenotype of pwMS on ocrelizumab, and identify clinical and immunological determinants of an effective vaccine response. MethodsThis was a single-centre, prospective cohort study. Peripheral blood samples were collected from ...
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