LSD1/KDM1A is essential for neural stem cell differentiation in mice
Falkenberry, E. C.; Reeves, M.; Scott, A. M.; Myrick, D. A.; Fallini, C.; Bassell, G. J.; Katz, D. J.
Show abstract
The proper regulation of neural stem cell differentiation is required for the proper specification of the central nervous system. Here we investigated the function of the H3K4me1/2 demethylase LSD1/KDM1A during neural stem differentiation in mice. Conditional deletion of LSD1 in nestin - positive neural stem cells results in 100% perinatal lethality after birth with severe motor coordination deficits, retarded growth and defects in brain morphology. Despite these severe defects, motor neuron progenitors and the initial motor neuron population are specified normally and motor neurons with normal morphology can be cultured from these mice in vitro. However, motor neurons cultured from mice lacking LSD1 in neural stem cells continue to inappropriately maintain critical neural stem cell proteins. Taken together these results suggest that, as in other mouse stem cell populations, LSD1 is required to deactivate the stem cell program to enable normal neural stem cell differentiation. However, unlike in other mouse stem cell populations, the inappropriate maintenance of the stem cell program during neural stem cell differentiation may compromise neuronal function rather than neuronal specification.
Matching journals
The top 12 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Glutathione S-transferase Pi (Gstp) Proteins Regulate Neuritogenesis in the Developing Cerebral Cortex 94%
- Lis1 mutation prevents basal radial glia-like cell production in the mouse 94%
- Deletion of a conserved genomic region associated with adolescent idiopathic scoliosis leads to vertebral rotation in mice. 94%
Similar papers in this journal
- Hindbrain rhombomere centers harbor a heterogenous population of dividing progenitors which rely on Notch-signaling 93%
- Using zebrafish to elucidate glial-vascular interactions during CNS development 93%
- Canonical Hedgehog Signaling Controls Astral Microtubules and Mitotic Spindle Orientation in Neural Progenitors and iPSCs 93%
Similar papers in this journal
- Autocrine regulation of adult neurogenesis by the endocannabinoid 2-arachidonoylglycerol (2-AG) 95%
- Loss of NMDA receptor function during development results in decreased KCC2 expression and increased neurons in the zebrafish forebrain. 93%
- GluN2A-mediated currents and calcium signal in human iPSC-derived neurons 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.