Comparative studies of genetic and phenotypic associations for 2,168 plasma proteins measured by two affinity-based platforms in 4,000 Chinese adults
Wang, B.; Pozarickij, A.; Mazidi, M.; Wright, N.; Yao, P.; Said, S.; Iona, A.; Kartsonaki, C.; Fry, H.; Lin, K.; Chen, Y.; Du, H.; Avery, D.; Schmidt, D. V.; Yu, C.; Sun, D.; Lv, J.; Hill, M.; Li, L.; Bennett, D. A.; Collins, R.; Walters, R. G.; Clarke, R.; Millwood, I. Y.; Chen, Z.; China Kadoorie Biobank Collaborative Group,
Show abstract
Proteomics offers unique insights into human biology and drug development, but few studies have directly compared the utility of different proteomics platforms. We measured 2,168 plasma proteins in 3,976 Chinese adults using both OLINK and SomaScan platforms and compared their genetic determinants and associations with traits and disease risk. For 1,694 proteins with one-to-one matched reagents, there was a modest between platform correlation (median rho=0.20). OLINK-proteins had fewer trans-pQTLs (766 vs 812 proteins) but more cis-pQTLs (725 vs 565) than SomaScan-proteins, including 342 with colocalising cis-pQTLs. Moreover, 1,095 OLINK- and 963 SomaScan-proteins showed significant associations with BMI, while 279 and 165 proteins were significantly associated with IHD, respectively. Addition of these IHD-associated proteins to conventional risk factors yielded NRIs for IHD of 15.3% and 17.1% for OLINK and SomaScan respectively. The results demonstrate the complementarity of different proteomic platforms and should inform assay selection in future population and clinical studies.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- An LDLR missense variant poses high risk of familial hypercholesterolemia in 30% of Greenlanders and offers potential for early cardiovascular disease intervention 93%
- Pathway-specific polygenic scores substantially increase the discovery of gene-adiposity interactions impacting liver biomarkers 93%
- Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium 93%
Similar papers in this journal
- The Phenotype-Genotype Reference Map: Improving biobank data science through replication. 94%
- Characterization of exome variants and their metabolic impact in 6,716 American Indians from Southwest US 94%
- Genetic regulation of the plasma proteome and its link to cardiometabolic disease in Greenlandic Inuit 93%
Similar papers in this journal
- Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study 93%
- Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization study 93%
- Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis 92%
Similar papers in this journal
- Elucidating the genetic architecture of DNA methylation to identify promising molecular mechanisms of disease 94%
- Genetic Polymorphisms Associated with Adverse Pregnancy Outcomes in Nulliparas 93%
- Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: The Framingham Heart Study 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.