Back

Multi-Omic blood analysis reveals differences in innate inflammatory sensitivity between species

2023-11-30 allergy and immunology Title + abstract only
View on medRxiv
Show abstract

Vertebrates differ greatly in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models to study human sepsis or inflammatory disorders. We compared transcriptomes of resting and LPS-exposed blood from six LPS-sensitive species (rabbit, pig, sheep, cow, chimpanzee, human) and four LPS-resilient species (mice, rats, baboon, rhesus), as well as plasma proteomes and lipidomes. Unexpectedly, at baseline, sensitive species already had enhance...

Predicted journal destinations

1
Nature Communications
483 training papers
Top 3% 17.7%
2
Frontiers in Immunology
140 training papers
Top 1% 7.8%
3
eLife
262 training papers
Top 3% 6.4%
4
Scientific Reports
701 training papers
Top 46% 5.9%
5
PLOS ONE
1737 training papers
Top 77% 5.9%
6
The Journal of Immunology
19 training papers
#1 5.9%
7
Nature Medicine
88 training papers
Top 0.6% 3.9%
8
Cell Reports Medicine
49 training papers
Top 0.5% 3.9%
9
Journal of Clinical Investigation
50 training papers
Top 1% 2.8%
10
iScience
74 training papers
Top 2% 2.8%
11
Cell
28 training papers
Top 0.4% 1.9%
12
Science Translational Medicine
40 training papers
Top 1% 1.5%
13
JCI Insight
63 training papers
Top 4% 1.5%
14
Proceedings of the National Academy of Sciences
100 training papers
Top 8% 1.5%
15
Communications Biology
36 training papers
Top 0.9% 1.5%
16
Cell Genomics
34 training papers
Top 4% 1.5%
17
Clinical Infectious Diseases
219 training papers
Top 18% 1.5%
18
eBioMedicine
82 training papers
Top 5% 1.3%
19
The Journal of Infectious Diseases
137 training papers
Top 11% 1.3%
20
Science Immunology
15 training papers
Top 0.4% 1.3%
21
PLOS Pathogens
35 training papers
Top 1% 1.3%
22
Genome Medicine
56 training papers
Top 7% 1.2%
23
Heliyon
57 training papers
Top 9% 0.9%
24
Blood Advances
16 training papers
Top 1.0% 0.9%
25
Journal of Medical Virology
95 training papers
Top 11% 0.9%
26
npj Vaccines
18 training papers
Top 0.6% 0.9%
27
Cell Reports
25 training papers
Top 3% 0.7%
28
mSphere
27 training papers
Top 2% 0.7%
29
Science Advances
52 training papers
Top 8% 0.5%