Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts
Vue, Z.; Ajayi, P. T.; Neikirk, K.; Murphy, A.; Prasad, P.; Jenkins, B. C.; Vang, L.; Garza-Lopez, E.; Mungai, M.; Marshall, A. G.; Beasley, H. K.; Killion, M.; Parker, R.; Anukodem, J.; Lavine, K.; Ajijola, O.; Mobley, B.; Dai, D.-F.; Exil, V.; Kirabo, A.; Ru Su, Y.; Tomasek, K.; Zhang, X.; Wanjalla, C. N.; Hubert, D. L.; Shao, J.; Phillips, M. A.; McReynolds, M.; Glancy, B.; Hinton, A.
Show abstract
This study, utilizing SBF-SEM, reveals structural alterations in mitochondria and myofibrils in human heart failure (HF). Mitochondria in HF show changes in structure, while myofibrils exhibit increased cross-sectional area and branching. Metabolomic and lipidomic analyses indicate concomitant dysregulation in key pathways. The findings underscore the need for personalized treatments considering individualized structural changes in HF.
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